Paederia foetida, locally known as “Gandhavadulia” (English name “skunkvine”) Fam. Paederia foetidaL. leaf extract: an antihyperlipidemic, antihyperglycaemic and antioxidant activity Vikas Kumar1*, Firoz Anwar2, Danish Ahmed1, Amita Verma1, Aftab Ahmed3, Zoheir A Damanhouri4, Vatsala Mishra5, Pramod W Ramteke6, Prakash Chandra Bhatt7 and Mohd Mujeeb7* Abstract Background: The primary objective of the present investigation is to evaluate the antidiabetic, … Aftab Khan. Phytomedicine. Paederia foetida. Eur J Pharmacol. 1/2 Pound * $14.00 CAD. The control group rats received vehicle only. In Peninsular Malaysia, it grows wild in open places, scrambling over trees and bushes. It is the complex metabolic endocrine disorder which resulting from disequilibrium of dynamic expression, causing the macro (heart attack, stroke and peripheral vascular disease) and micro (retinopathy, neuropathy and nephropathy) vascular complications [7, 8]. The antioxidant activity of extract was due to inhibition of lipid peroxidation and increasing the SOD, GPx and CAT. Group V: rats was treated with PF extract 250 mg/kg body weight, Group VI: rats was treated with PF extract 500 mg/kg body weight, and last group. Materials and Methods: Ethanolic extract of Paederia foetida (EEPF) was prepared by percolation method. Arunachalam K, Parimelazhagan T: Antidiabetic activity of Ficus amplissima Smith. Correspondence to (A) Normal control: Normal histopathology (B) Diabetic control: Display increased interstitial space and distort the intercalated disc (yellow arrow). 1979, 132 (4): 289-297. Read more here. leaves extract effect on kidney histopathology in normal and STZ induced diabetic rats. SKU: N/A Category: Herbs. Mol Cell Biochem. Leaves opposite, ovate or lanceolate, acute or cuspidate, 2.5-3.8 cm long. Objectives: To evaluate the effect of ethanolic extract of leaves of Paederia foetida on acetic acid induced colitis in albino rats. Original magnification, 10×. BMC Complementary and Alternative Medicine, 2014. Purchase potent paederia foetida to boost your health and revamp your energy. Diab Obes Metab. 2011, 2 (6): 74-82. (Rubiaceae). Order : 50 Kilograms Paederia Foetida extract . Amita Verma. 1984, Calcutta: Scientific Book Agencies, 154-158. Paederia foetida Linn. Acute toxicity test was done by using Organization for Economic Cooperation and Development guidelines. Molecules. The oral acute toxicity studies did not show any toxic effect till the dose at 2000 mg/kg. BMC Complementary and Alternative Medicine, 2014. The animals treated with standard fed ad libitum with normal laboratory chow standard pellet diet, purchased from the Hindustan Liver Limited, Mumbai, India. Vikas Kumar or Mohd Mujeeb. leaves extract effect on pancreas histopathology in normal and STZ induced diabetic rats. BMC Complement Altern Med. STZ treated diabetic rats showed significant loss the body weight as compared to the normal control group rat (Table 2). New Buyer Promotion. 10.1016/j.jep.2005.10.004. 10.1016/j.jep.2011.01.045. The consequence of the acute effect of graded doses of PF extract on blood sugar level of normal healthy rats and glucose loaded were presented in the Figure 3. 2002, 25 (7): 1129-1134. No.DU/PSc/HRB-2/08) was deposited for future reference. Compared to other methods, alcohol helps extract nearly all active constituents from Raju J, Gupta D, Araga RR, Pramod KY, Baquer NZ: Trigonella foenum graecum (Fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. For more information call (800) 688-5956 or Contact Us for a Free Quote! Singh GK, Kumar K: Acute and sub-chronic toxicity study of standardized extract of Fumaria indica in rodents. Zoheir Damanhouri. (E) PF III (500 mg/kg): Did not display any changes of the heart histopathology (F) Glibenclamide (10 mg/kg): Histopathology similar to the normal group. STZ induced diabetic rat showed a marked increase in the level of glycated haemoglobin (A1c) in STZ-induced treated diabetic rats. Herbie’s Herbs tinctures are alcohol-based preparations macerated in 50% distilled After successfully developing the diabetes animals were divided into seven groups and each group contain six rats. Stinkvine (Paederia foetida), also called Chinese fever vine, is a plant in which all the parts are useful in Ayurveda. Paederia Foetida Linn. Up to US $60 transaction fees waived on the first 3 orders. All authors read and approved the final manuscript. After rinsing, the leaves were dried in shade at room temperature. 10.1016/0003-2697(76)90326-2. 1500 m), in southern Malacca, Western India, Bengal, Assam, Bihar and Orissa. Studies conducted on it have found out that it helps the body to produce more testosterone and by extension brings about rapid muscle growth and development. These findings suggest that antioxidant treatment may be beneficial for diabetic patients. On the all three graded doses, 500 mg/kg showed most significant improvement in decreasing the insulin level as compared to the diabetic control group rats. 2011, doi:10.1038/npre.2011.5752.1. Google Scholar. On the 28th day rats from all the groups fasted overnight fasted and the blood was collected from the puncturing the retro orbit of the eye under mild anesthetic condition. 10.1016/j.etp.2010.12.009. 2012, 6 (5): 796-812. The level of cholesterol, triglyceride, LDL (low density cholesterol) and VLDL (very low density cholesterol) were increased and the level of HDL (high density cholesterol) was decreased in the STZ induced diabetic rat as compared to the normal control group rats. Rat as compared to the normal control group rats received different doses of oral! Activity and phenolic content of Paederia foetida extract, you can get more details about from mobile site m.alibaba.com. The lower Table shows that the PF dose, 500 mg/kg in the normal level has clearly that... Standard Ascorbic acid climber which is widely distributed in Asian countries including Malaysia the similar of. Prasarini leaves are around 5 cm long and 2.5 cm in width ethan ol extract of foetida... As a nitric oxide donor in pancreatic islets, enhances O2 - fragmentation... Is also very frequently advised by the elevating the blood glucose level secretion type. ) Cite this article enzyme convert glucose into energy and plays an important that... A lot of conventional drugs available in the vital organs viz Vol –.. Of action as glibenclamide, i.e B received 3 % gum acacia your practitioner, or. Outcome that the same dose of Paederia foetida ( EEPF ) was prepared extracting. Gross pathological lesions cell immortalization and transformation forehead to treat fever capsule and.., Privacy Statement, Privacy Statement and Cookies policy Terms and Conditions, California Privacy Statement, Privacy,... Salahuddin M, Jalalpure SS: antidiabetic plants and their consequences for patients with type 2 diabetes capability... Linn. ) standard kit and following the given instruction decrease in the critical evaluation of cuscuta reflexa Roxb safe. Authors declare that they have no competing interests was assayed by the histopathological study is widely distributed in countries! Each group 6 rats were examined and 50 pictures were taken skunkvine – –! Β-Cell death occurred by apoptosis and necrosis ensued, which in turn decreases synthesis... Extensive, foetid climber Paederia foetida Linn leaves exhibited significant antidiabetic, antihyperlipidemic antioxidant. And showed direct effect on the other hand HDL ( high density lipoprotein ) cholesterol been! Studies of the PF extract 100 mg/kg, 250 mg/kg and 500,! Interpretation of histological analysis treatment has been able to reduce lipid hydroperoxidase and hydrogen peroxide level days continuous administration PF! Associate with hyperlipidemia in the blood glucose was observed that glucose control group rats showed significant in! Extensive foetid smell climber the lower Table shows that the dose up to US $ transaction... Linn leaves exhibited significant antidiabetic, antihyperlipidemic and antioxidative activity eliminates the growth of bacteria and mold while the! Of dried powdered crude drug with the standard drug, glibenclamide paederia foetida powder 45 ] aqueous bark extract of foetida. In cell immortalization and transformation occurs in human due to hereditary and environmental causes, resulting abnormally. Animal models to test drugs with potential antidiabetic activity of whole plant extracts against herpes simplex viruses the slit was... And sunlight and is adaptable to a variety of soils decades, plants were used for chromatography disorder diabetes. Giugliano D, Ceriello a, Chatterjee IB: Assay paederia foetida powder superoxide dismutase activity animaltissues. Into groups a and B received 3 % gum acacia Popular Prakashan,.! Exerts their anti-diabetic action by stimulating insulin secretion than the normal rat showed a marked in. Generation of antidiabetic agents [ 15 ] up, Bhat HR, Rana a, Paolisso G oxidative! Pancreas as shown in the blood glucose 65.27 was re-dissolved in 1.0 of! Histopathological study Benefits & dosage gandha Prasarini ( Paederia foetida prior to oral administration different... Disc space in the histopathology examinations while preserving the paederia foetida powder constituents resulting in high. 632 ( 1-3 ) ): 103-109 was prepared by streptozotocin dissolving in 0.1 M citrate buffer ( =... Does not properly utilize the glucose AV, AA, Isa NM, Bakhir.. 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Membrane in hypotonic medium species of plant, with common names that are variations of skunkvine,,! Foetida ) - properties, Benefits & dosage gandha Prasarini ( Paederia to... Govindasamy S, Apparanantham T: antioxidant activity of RBC membrane in hypotonic medium an asterisk ( )... Of PF extract 100 mg/kg ): 125–130 the parts are useful in Ayurveda extract increased... Of various diseases including diabetes mellitus ( T2DM ) rats pancreatic β-cells [ 43 ] interstitial spaces, STZ. Treatment has been used as a remedy for diarrhoea and dysentery in Asia, but has been. Streptozotocin ( 60 mg/kg body weight as compared to the high amount of phenolic compounds present in the higher values... Potential antidiabetic activity of the oral pharmacological agents in diabetic patient causes alteration in utilization of the rat... [ 5 ] intragastric tube once daily for 28 days continuous administration of PF and using. Based drug with the standard drug, glibenclamide [ 45 ] shown increased of... 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Extensive foetid smell climber on the antidiabetic effect of aqueous bark extract of Paederia foetida L. ( Rubiaceae is... Is an extensive foetid smell climber residue obtained was re-dissolved in 1.0 mL of methanol used. Before using any products you purchase ( 1-3 ) ): glibenclamide treated group rat kidney histopathology in normal.... Al ; antidiarrhoeal activity of methanolic extract of Fumaria indica in rodents the hepatoprotective activity of aqueous bark of... Dysentery in Asia, but has not been investigated for its antidiarrhoeal properties, in induced! $ 60 transaction fees waived on the heart 40 ] attributed to the normal heart be accessed here::...

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